bendamustine

基本解释

Objective: To synthesize bendamustine.
目的:合成盐酸苯达莫司汀。
Background : Bendamustine, a bifunctional alkylating agent with anticipated purin-like properties is active in metastatic breast cancer (MBC) patients.
苯达莫司汀，具有烷化剂和嘌呤类似的双相功能可以在转移性乳腺癌（MBC）患者中发挥作用。
Results: The structure of the target compound was confirmed by MS,1H-NMR,IR analysis.The total yield of bendamustine was 33.5%.
结果:目标化合物的质谱、核磁共振氢谱、红外光谱均与文献报道相吻合;总收率为33.;5%25。
This multicenter phase II trial defines the toxicity and activity of bendamustine in heavily pretreated patients.Patients and methods: Fifty-one patients were included.
本实验为多中心II期临床试验，旨在定义苯达莫司汀在治疗失败乳腺癌患者中的毒性和治疗效应。
Conclusion : Single-agent bendamustine is an active treatment in patients with MBC independent of the previous treatment.The low toxicity profile favors its use as a single agent.
苯达莫司汀单药治疗MBC具有疗效，而其低毒性的特性支持其采用单药治疗。