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Knock out of GATA-6 is embryonic lethal due to defects in formation of the heart tube and a failure to develop extraembryonic endoderm (4). GATA-6的基因敲除會引起心髒導琯的形成缺失，也不能發育胚外內胚層，這些會導致胚胎致死[4]。 www.cst-c.com.cn